Research Review of 7-Keto DHEA

7-keto-DHEA is really a metabolite (breakdown product) of DHEA (dehydroepiandrosterone). DHEA is formed in the adrenal glands, little glands that live just above the kidneys. DHEA is really a “parent hormone,” meaning that it gets changed into other hormones, such as for example testosterone and estrogen. Unlike DHEA, 7-keto will not convert in to hormones. Hence, 7-keto could be taken without the person experiencing side-effects from increased amounts of hormones. These side-effects may be observed in individuals who simply take DHEA. Known reasons for which people simply take 7 – keto include : trying to aging process., produce thermogenesis (increased human body heat), increase muscle mass, increase thyroid function, improve immune function, improve memory, and slow the increase their metabolic rates.

What Does The Medical Research Say About 7-Keto DHEA?

Research has shown that after 7-keto is formed within the body, it cannot be converted back into DHEA nor can it be converted into other hormones. A little 2007 study demonstrated that 7-Keto by itself and also in conjunction with a combination of calcium citrate, green tea extract extract, ascorbic acid, chromium nicotinate and cholecalciferol (HUM5007), did raise the resting metabolic rate of overweight/obese adults while they were on a calorie-restricted diet. In the 40 subjects who completed the research, resting metabolic rate (RMR) decreased by 3.9 a little while on placebo. During treatment with 7-keto, RMR increased by 1.4%. During treatment with HUM5007, RMR increased by 3.4%. Both outcomes were statistically significant (P= 0.001). There have been number sigificant adverse events (side-effects). In other words, 7-Keto reversed the decline in RMR usually observed in individuals who are dieting.
A report on 30 heavy adults demonstrated a 6.3 pound reduction in human body fat, versus 2.1 pounds on placebo.
A 2003 study indicated that patients with Raynaud’s phenomenon (abnormal vasoconstriction in the fingers and toes in response to cold) may be assisted by taking 7-Keto, which was touted in the study as a “thermogenic” (heat-producing) compound. The authors concluded that 7 – keto may aid by both inhibiting vasospasm as well as by raising RMR.
A report from 2000 on 22 healthier men assessed the safety and effects of doses of 7-keto at 50 mg, 100 mg, and 200 mg. Measured were free and total testosterone, dihydrotestosterone, estradiol, cortisol, thyroxin, and insulin. There have been no significant differences in laboratory values or negative effects between placebo and treatment groups. Moreover, no differences in vital signs, blood chemistry, or urine chemistry were seen. The researchers concluded that 7-keto was safe and well-tolerated in healthy men at doses up to 200 mg, for periods up to at least four weeks.

Some early evidence has been presented that indicates 7-Keto might help in the body’s successful immune response. A 4 week human study [8] was performed to ascertain the results of 7 – keto on women and aged men. Taking 100 mg twice daily, improved immune function was shown by the participants, reduced blood pressure and increased white blood cells.

Research data from mice indicates 7 – keto might enhance the memory of both old and young mice.

No significant effects were found on thyroid stimulating hormone (TSH), T4, or other hormones. A 1999 study revealed any particular one hour of cross training three times each week plus 200 mg of 7 – a significant reduction was demonstrated by Keto in body fat and body weight, with increases in T3 but no change in TSH (thyroid stimulating hormone). This suggests a rise in RMR without negative feedback on the thyroid hormone system. Yet another study demonstrated that the commercial weight loss supplement containing 7-keto DHEA but in addition containing DHEA in addition to other known weight loss agents (i.e. caffeine, green tea extract extract, citrus aurantium, and so on.), promoted weight loss. This study will not directly support the usage of 7-keto DHEA. So what can consumers reason about 7-Keto DHEA? – Early data indicate that the compound is very likely safe. -7-keto DHEA might function as a highly effective weight loss supplement. -7-Keto may possess some thermogenic properties. – Basal metabolic rate might be slightly improved by 7-Keto. – Thyroid hormone degrees might be somewhat increased, possibly without the feared “negative feedback” influence on the your body’s natural thyroid hormone system. – Memory and Possible positive effect is suggested by some early, tantalizing data on both immune function. – Even though early data is very promising, most main-stream researchers still find it too soon to reason that 7-Keto is really a certain aid in the struggle for successful, enduring weight reduction. – As always, their health care provider should be consulted by one prior to starting any nutritional supplement, particularly if the individual is pregnant, nursing, or has any health issues.